Surgical Site Infection
Over 290,000 SSIs have been estimated to occur annually in the US. The vast majority of surgical site infections (SSIs) are caused by bacteria which enter the surgical site during a procedure. Despite the development of best practices including patient optimization, careful operative technique, and appropriately timed systemic antimicrobial therapy, the incidence of SSI can be as high as 20%, depending on the type of surgery. Over 3 million procedures in the US annually are at high risk of SSI, primarily in orthopaedic, cardiac, and colorectal surgery.
As many as 80% of SSIs are estimated to involve biofilm, which contains bacteria that are highly tolerant to antimicrobials. SSI treatment often requires additional surgery, imposing high morbidity and high costs.