Local delivery can provide the high antibiotic levels required to kill biofilm while avoiding toxicity from systemic exposure. However, not all local delivery is equally effective.
Local delivery must provide high antibiotic levels that are sustained long enough for the antibiotics to act. If the release rate is too slow, high levels aren’t reached. If release is too fast, antibiotic levels aren’t sustained for sufficient time as the antibiotics diffuse away. Striking this balance to provide the desired timing of drug release is the foundation of our approach to local delivery.
Learn more about our approach