About 14 million surgical procedures in the US annually are associated with moderate-to-severe postoperative pain. Patients often experience moderate pain at rest for up to three days and severe pain with basic activities like joint motion or coughing for up to seven days postoperatively. Current recommendations support treatment of postoperative pain using multimodal analgesia, which combines drugs from multiple classes to reduce the need for opioids. Local anesthetics are potent in reducing severe pain by blocking neural conduction from local pain receptors but have a short effective duration (up to 8-12 hr). A sustained-release local anesthetic acting for at least three days would be an ideal foundation for effective multimodal analgesia, safely providing local pain control while minimizing the need for opioids.
Learn more about SBG004 for postoperative pain