SB Gel
SB Gel is a proprietary sustained release carrier which can be easily loaded with drugs and applied as a liquid. After injection, SB Gel thickens into a semi-solid material based on warming to body temperature based on a unique property called a lower critical solution temperature (LCST). SB Gel then releases its drug payload over multiple days and subsequently dissolves. SB Gel is water-based, forms a gel without chemical reaction or solvents, and dissolves with minimal acid generation. It is formulated in terminally sterilized, prefilled syringes, and mixed with active drug immediately before dosing.
- Injectable
- Can be dosed by injection or wound filling
- Conforms to complex wound surfaces for direct delivery
- Sustained drug release
- Slower release profile than other gels or emulsions
- Adjustable release duration from days to weeks
- Dissolves over time
- Forms a biocompatible gel that dissolves after drug release
- Solvent-free and reaction-free with minimal acid generation
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SB Gel forming upon injection into warm water.
Local Delivery
Formulations based on SB Gel are ideally suited for local drug delivery, sustaining higher and more effective concentrations of drugs at the dosing site than would be possible with systemic administration.
Over 14 million patients undergoing surgical procedures annually in the United States require treatment for moderate to severe postoperative pain lasting at least 3 days. Although extended-release local anesthetics have been developed, there is substantial room for improvement to extend the duration of analgesia provided by local anesthetics and further reduce opioid consumption. SBG004 is designed to treat pain for at least 72 hours, covering the full duration of moderate-to-severe pain in most patients.
Learn more about SBG004 for postoperative pain
Surgical site infection (SSI) is among the most common and costly types of hospital-acquired infections. Local antimicrobial delivery can provide the high levels required to kill pathogenic bacteria throughout a surgical site with reduced systemic exposure. SBG003 is designed to sustain high antibiotic levels throughout a surgical site for multiple days, outperforming conventional systemic dosing and other local delivery technologies.