Formulations based on SB Gel are ideally suited for local drug delivery, sustaining higher and more effective concentrations of drugs at the surgical site than would be possible with systemic administration.
For treatment of postoperative pain, local dosing is already routinely performed with local anesthetic drugs by tissue infiltration and nerve block, blocking neural conduction from local pain receptors. Unfortunately, while pain can last for three to seven days, local anesthetics alone are effective for no more than 8-12 hours. Although extended-release local anesthetics have been developed, there is substantial room for improvement to extend the duration of analgesia provided by local anesthetics and further reduce opioid consumption. SBG004 is designed to provide potent local analgesia for at least 72 hours, covering the full duration of moderate-to-severe pain in most patients.
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For prevention of surgical site infection (SSI), local delivery can provide the high antibiotic levels required to kill pathogenic bacteria throughout a surgical site while avoiding toxicity from systemic exposure. However, not all local delivery is equally effective. Local delivery must provide high antibiotic levels that are sustained long enough for the antibiotics to act. If the release rate is too slow, high levels aren’t reached. If release is too fast, antibiotic levels aren’t sustained for sufficient time as the antibiotics diffuse away. Striking this balance to provide the desired timing of drug release is the foundation of our approach to local delivery. SBG003 is designed to sustain high antibiotic levels for multiple days, outperforming conventional systemic dosing and other local delivery technologies.
Learn more about SBG003 for prevention of SSI